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In vitro reports, 25C-NBOMe has become proven to show cytotoxicity on neuronal mobile traces SH-SY5Y, PC12, and SN471, and also the compound was additional potent than methamphetamine at cutting down the visibility on the respective cells; the neurotoxicity with the compound consists of activation of MAPK/ERK cascade and inhibition of Akt/PKB signaling pathway.

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Notes: (one) TAAR1 exercise of ligands may 25I-NBOMe Synthesis differ noticeably between species. Some brokers which are TAAR1 ligands in some species are not in other species.

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